T.A.L.O.S stands for Tyrant Armored Lethal Organic System. It uses an armor-plated T-103 as its base and is armed with an MRL (Multiple rocket launcher). Umbrella has tested it against soldiers, tanks and gunships and it defeated them all. A specially implanted chip allows the Red Queen to control it.

There is a shooting gallery minigame.

Sergei and his Ivan bodyguards were present during RE1 and RE2 under Spencer’s orders.

Claire A/Leon B are the events depicted as canon in the game.

Nicholai Ginovaef is actually a member of Monitor, an internal espionage organisation that keeps tabs on Umbrella employees and carries out covert assignments. His codename is Silver Fox and he answers directly to Sergei.

Spencer and Hunk remain a mystery, although a new picture of Hunk is in the game.

Umbrella made 10 clones of Sergei and infected all of them. Every Tyrant you fought in the previous games was a clone of Sergei, even Nemesis.

After the Raccoon City incident, Spencer hired top lawyers and used false witnesses to create the appearance that the catastrophe was the result of a government conspiracy, but the court ruled against Umbrella after its computer files on viral weaponry came to light.

Wesker theorises that the personality of the host can determine the violence of the mutations when infected, and wonders what that says about himself.